Maintaining “robust” encendocannabinoid signaling – which can be done through through the intake of cannabinoids – may provide protection against stress and stress-related disorders, according to a new study published in the journal Seminars in Immunology, and published online by the National Institute of Health.
According to the study, “CB1 receptor-endocannabinoid signaling is activated by stress and functions to buffer or dampen the behavioral and endocrine effects of acute stress.”
It continues; “Its role in regulation of neuronal responses is more complex. Chronic variable stress exposure reduces endocannabinoid-CB1 receptor signaling and it is hypothesized that the resultant deficiency in endocannabinoid signaling contributes to the negative consequences of chronic stress. On the other hand, repeated exposure to the same stress can sensitize CB1 receptor signaling, resulting in dampening of the stress response.”
Researchers conclude that; “Data are reviewed that support the hypothesis that CB1 receptor signaling is stress responsive and that maintaining robust endocannabinoid/CB1 receptor signaling provides resilience against the development of stress-related pathologies.”
Given that cannabis activates and regulates the body’s cannabinoid receptors, this study gives strong indication that cannabis consumption may provide a defense against stress, and stress-related disorders.
The study was conducted by researchers at the Medical College of Wisconsin’s Neuroscience Research Center and Department of Pharmacology and Toxicology.
The post Cannabis May Provide Resillience Against Stress-Related Patholigies, According to New Study appeared first on The Joint Blog.
I am sometimes amazed at the ability of some legalization activists – especially the true believers who want to hold out for full legalization until they can pass a law with no limits on the amount of marijuana an adult can grow or possess, and no limits on who can sell marijuana to whom – to listen to each other and to convince themselves what they are hearing is a reflection of public opinion in this country. This ‘tomato model’, as it is sometimes called, has little appeal beyond those of us who smoke.
Those of us who support marijuana legalization have been thrilled to see the many national polls showing a majority of the country finally support the full legalization of marijuana. According to the Gallup polling organization, 58% of the population now support the legalization, regulation and taxation of marijuana for adults, regardless of why one smokes. The support for legalization, at only 12% when Gallup first asked this question in 1969, the year before NORML was founded, has slowly gained acceptance – with a modest decline in support between 1977 to 1990, followed by a steady increase that finally broke the 50% mark about three years ago. Several other national polls have since confirmed this result.
However, only about 14% of the country are marijuana smokers – 86% are not. The continued support of a majority of those non-smokers is crucial if we are to continue to move full legalization forward across the country.
The organization Oklahomans for Health officially launched its petition drive to legalize medical cannabis last week with a press conference held by Senator Constance Johnson, a longtime supporter of legalizing medical cannabis.
Advocates will be required to collect roughly 155,000 valid signatures in order for the initiative to qualify for this November’s ballot.
Under the proposed law, the possession, use and state-licensed distribution of cannabis will be legal for those with a qualifying medical cannabis, such as cancer, HIV/AIDS and multiple sclerosis, as long as they receive a recommendation from a physician. The initiative – which is a constitutional amendment – was recently approved by the Oklahoma Secretary of State, giving the group the go-ahead to begin collecting signatures.
Those interested in helping this campaign, and those in Oklahoma wanting to sign the initiative, should click here.
The post Oklahoma Initiative Drive to Legalize Medical Cannabis Underway appeared first on The Joint Blog.
A study published in last month’s issue of the journal Schizophrenia Research has found that cannabis use, regardless of how much and how often, does not increase an individual’s risk of psychosis.
For the study, “170 people at CHR of psychosis were assessed at baseline on severity of alcohol, tobacco and cannabis using the Alcohol and Drug Use Scale. Participants were recruited across three sites over a four year period as part of the Enhancing the Prospective Prediction of Psychosis (PREDICT) study. Predictors of conversion to psychosis were examined using Cox proportional hazards models.”
After conducting the study, researchers found that “low use of alcohol, but neither cannabis use nor tobacco use at baseline, contributed to the prediction of psychosis in the CHR sample.”
The post New Study: Cannabis Doesn’t Increase Risk of Psychosis, Alcohol Does appeared first on The Joint Blog.
A new study published in the most recent issue of the journal Addictive Behavior has found that dabbing – the process of consuming cannabis extracts such as butane hash oil – is safe and causes no more accidents than cannabis in any other form, despite consumers perceiving there being a greater risk.
According to the study; “A new method for administering cannabinoids, called butane hash oil (“dabs”), is gaining popularity among marijuana users. Despite press reports that suggest that “dabbing” is riskier than smoking flower cannabis, no data address whether dabs users experience more problems from use than those who prefer flower cannabis.”
With this in mind, the study aimed to “gather preliminary information on dabs users and test whether dabs use is associated with more problems than using flower cannabis.”
After conducting the study, researchers found that; “Analyses revealed that using “dabs” created no more problems or accidents than using flower cannabis.”
These results were despite the fact that; “The use of butane hash oil has spread outside of the medical marijuana community and users view it as significantly more dangerous than other forms of cannabis use.”
Although more quantitative data is needed before a clear conclusion is drawn that dabbing is safe, the results of this study are promising.
The post New Study: Despite Perceived Risks, Dabbing is Safe appeared first on The Joint Blog.
By Associated Press
Sen. Jorge Larranaga had been a favorite to represent the National Party this year and strongly opposes the new law, which puts the ruling Broad Front government at the center of a regulated marijuana industry. The government’s aim is to defeat organized crime by producing cheaper, better, legal weed and selling it in pharmacies to registered adults.
“We are going to overturn this law that legalized marijuana growing. Nobody plant anything! Don’t plant anything because we’re going to knock it down!” Larranaga had said ahead of Sunday’s primary.
Other leading candidates to succeed President Jose Mujica in October are on the record favoring the legal cultivation and purchase of marijuana for personal use.
The right-wing National Party’s surprise winner by a wide margin was congressman Luis Lacalle Pou, who supports home-grown marijuana and says he would keep much of the law as is.
But political analyst Daniel Chasquetti cautioned against seeing Sunday’s results as a sign that sentiment is shifting in favor of Uruguay marijuana law, which Congress approved in December despite overwhelming opposition in opinion polls. He said Lacalle Pou’s victory has more to do with the feeling in his party that he stands a better chance of defeating the Broad Front in October.
Lacalle Pou, 40, is the son of former President Luis Alberto Lacalle, who governed Uruguay from 1990 to 1995.
The National Party is backed by about a third of Uruguay’s electorate, so Lacalle Pou would need to persuade many centrist voters to abandon the governing bloc. The more likely winner in October is former President Tabare Vazquez, who won the center-left Broad Front’s primary Sunday and supports the new law.
The center-right Colorado Party chose Sen. Pedro Bordaberry, who is against legalizing marijuana, but apparently lacks the votes to win.
Lacalle Pou was an early supporter of legalizing marijuana, offering a proposed law to do so even before Mujica’s government came on board. But the congressman would let private enterprise take over the industry, reducing the government role and keeping the pot business out of pharmacies.
“The idea of pot-growing clubs doesn’t really bother me,” Lacalle Pou told the Uruguayan newspaper El Pais in an interview. But “I don’t believe that the state should produce marijuana or sell it or register the people who smoke it.”
Senate Bill 1035, a proposal to legalize cannabis extracts for medical purposes in South Carolina, has been signed into law by Governor Nikki Haley.
Under the new law, those with epilepsy will be authorized to possess and use cannabis oil that’s low in THC (tertahydrocannabinol), and high in CBD (cannabidiol), given they receive a recommendation from a licensed physician. The Medical University of South Carolina will distribute the medicine to patients.
In addition to legalizing cannabidiol, the proposal will establish a clinical trial at the Medical University of South Carolina, which will study the effects of cannabidiol in controlling seizures.
The measure was passed unanimously by the Senate, and was approved 92 to 5 in the House.
With Senate Bill 1035 becoming law, South Carolina joins Utah, Mississippi, Alabama, Iowa, Tennessee, Wisconsin and Kentucky as states that have legalized cannabidiol in 2014.