An interesting new study published in this month’s issue of the journal Basic Research in Cardiology has found that the endocannabinoid system plays a key role in protecting the body in the early development of ischemic cardiomyopathy, indicating that cannabis, which regulates and activates the body’s cannabinoid receptors, may provide a potential treatment option for the condition.
Ischemic cardiomyopathy, which is inadequate oxygen delivery to the myocardium (the heart muscle), is most commonly caused by coronary artery disease and can lead to heart failure.
According to the study; “Ischemic heart disease is associated with inflammation, interstitial fibrosis and ventricular dysfunction prior to the development of heart failure. Endocannabinoids and the cannabinoid receptor CB2 have been claimed to be involved, but their potential role in cardioprotection is not well understood. We therefore explored the role of the cannabinoid receptor CB2 during the initial phase of ischemic cardiomyopathy development prior to the onset of ventricular dysfunction or infarction.”
For the study, researchers at the University Clinical Centre Bonn’s Department of Cardiac Surgery used CB2 [cannabinoid receptor type 2]-deficient mice, which “underwent daily brief, repetitive ischemia and reperfusion (I/R) episodes leading to ischemic cardiomyopathy. The relevance of the endocannabinoid-CB2 receptor axis was underscored by the finding that CB2 was upregulated in ischemic wild type cardiomyocytes and that anandamide level was transiently increased during I/R.”
Researchers found that; “CB2-deficient mice showed an increased rate of apoptosis, irreversible loss of cardiomyocytes and persistent left ventricular dysfunction 60 days after the injury, whereas wild type mice presented neither morphological nor functional defects. These defects were due to lack of cardiomyocyte protection mechanisms, as CB2-deficient hearts were in contrast to controls unable to induce switch in myosin heavy chain isoforms, antioxidative enzymes and chemokine CCL2 during repetitive I/R. In addition, a prolonged inflammatory response and adverse myocardial remodeling were found in CB2-deficient hearts because of postponed activation of the M2a macrophage subpopulation.”
Having discovered this, researcher conclude; “Therefore, the endocannabinoid-CB2 receptor axis plays a key role in cardioprotection during the initial phase of ischemic cardiomyopathy development.”
The study, which was published online by the U.S. National Institute of Health, can be found by clicking here.
The post Cannabis May Protect Against Ischemic Cardiomyopathy appeared first on The Joint Blog.
On Monday, July 7th, the Washington State Liquor Control Board will distribute licenses to businesses across the state planning to sale recreational cannabis. Following the distribution of the licenses, a 24-hour moratorium on sales will begin, with stores able to open their doors to anyone 21 and older the following day, Tuesday, July 8th.
The name and location of the accepted businesses will be announced by the Board on Monday. In total 334 applications were accepted for recreational cannabis retail outlets, with final inspections for most of these locations taking place in recent days.
Under Washington State law, anyone 21 and older can possess, use and purchase up to an ounce of cannabis. An individual is also allowed to possess, use and purchase up to 72 ounces of cannabis-infused liquids, and up to 16 ounces of cannabis-infused solids.
The post Legal Recreational Cannabis Sales Begin In Washington State On Tuesday appeared first on The Joint Blog.
If approved by voters this November 4th, the initiative will legalize the possession, use and transfer of up to an ounce of cannabis for adults 21 and older. Similar initiative have been approved in the Michigan cities of Detroit, Lansing, Ferndale, Jackson, Flint and Grand Rapids.
Signatures have also been submitted this year for legalization initiatives in a dozen other Michigan cities and a county, including Oak Park, Hazel Park, Utica, Lapeer, Port Huron, Onaway, Harrison Township, East Lansing, Clare, Saginaw, Mount Pleasant and Benzie County.
“Berkley is another community in Michigan that’s going to be liberating itself come November”, Beck tells us. “We look forward to at least a dozen other cities doing the same.”
The Safer Michigan Coalition is continuing to collect signatures in the cities of Portage, Huntington Woods, Pleasant Ridge, Grosse Point Park and Montrose.
The post Initiative to Legalize Cannabis Placed on November’s Ballot in Berkley, Michigan appeared first on The Joint Blog.
Sales are scheduled to begin at 8 a.m. Tuesday morning at and estimated 15 to 20 shops the state says are eligible to receive a license. A spokesman for Anal... From: Regulate Marijuana Views: 324 6 ratings Time: 02:52 More in Nonprofits & Activism
Washingtonians will soon join residents of Colorado in the regulated cannabis market. The Washington State Liquor Control Board (WSLCB) suggests it will issu... From: Regulate Marijuana Views: 239 6 ratings Time: 01:41 More in Nonprofits & Activism
Proponents of a statewide initiative to regulate the commercial production and retail sale of marijuana have turned in 145,000 signatures to the Secretary of State’s office. The total is almost twice the number of signatures from registered voters necessary to place the measure on the 2014 electoral ballot.
State officials have until August 2 to verify the signatures.
The proposed ballot initiative (Initiative Petition 53) seeks to regulate the personal possession (up to eight ounces), commercial cultivation, and retail sale of cannabis to adults. Taxes on the commercial sale of cannabis under the plan are estimated to raise some $88 million in revenue in the first two years following the law’s implementation. Adults who engage in the non-commercial cultivation of limited amounts of cannabis (up to four plants) for personal use will not be subject to taxation.
A statewide Survey USA poll released last month reported that 51 percent of Oregon adults support legalizing the personal use of marijuana. Forty-one percent of respondents, primarily Republicans and older voters, oppose the idea. The poll did not survey respondents as to whether they specifically supported the proposed 2014 initiative.
Alaska voters will decide on a similar legalization initiative in November. Polling data shows that 55 percent of registered voters back the plan, while 39 percent oppose it. Florida voters will also decide in November on a constitutional amendment to allow for the physician-authorized use of cannabis therapy. A May 2014 Quinnipiac University poll reported that Floridians support permitting physicians to authorize medical marijuana to patients by a margin of 88 percent to 10 percent.
Footage: Oregon NORML Presents, 5-4-2008 - http://ornorml.org From: OregonNORML Views: 35 1 ratings Time: 05:38 More in News & Politics
Washington’s first wave of state-licensed cannabis retail stores are anticipated to open for business next week. Initiative 502, approved by a majority of voters in November 2012, authorizes the establishment of state-licensed cannabis producers and retail sellers.
The state’s Liquor Control Board is expected to begin issuing licenses on Monday, July 7. An estimated 20 retail stores are anticipated to open their doors later in the week. Similar state-sanction stores have been operating in Colorado since January 1.
With only a small number of stores likely to be operational at first, regulators anticipate that consumers’ demand for legal cannabis may initially outpace supply. In Colorado, retailers struggled initially to meet consumer demand, resulting in temporarily inflated retail prices for cannabis. Prices have steadily fallen in Colorado as additional retailers have opened for business.
Since the passage of Initiative 502, police filings for low-level marijuana offenses have fallen from over 5,000 annual arrests to just over one hundred.
[UPDATE: Here is a list (c/o of the Seattle Post Intelligencer) of the first 24 state-licensed stores:
WHIDBEY ISLAND CANNABIS COMPANY — 5826 S KRAMER RD STE, Langley
WESTSIDE420 RECREATIONAL — 4503 OCEAN BEACH HWY, Longview
VERDE VALLEY — 4007 MAIN ST, Union Gap
TOP SHELF CANNABIS – 3857 HANNEGAN RD, Bellingham
THE HAPPY CROP SHOPPE — 50 ROCK ISLAND RD, East Wenatchee
SPOKANE GREEN LEAF — 9107 N COUNTRY HOMES BLVD, Spokane
SPACE – 3111 S PINE ST, Tacoma
SATORI/INSTANT KARMA — 9301 N DIVISION ST, Spokane
NEW VANSTERDAM — 6515 E. MILL PLAIN BLVD, Vancouver
MARGIE’S POT SHOP — 405 E STUEBEN, Bingen
MAIN STREET MARIJUNA — 2314 MAIN ST, Vancouver
HIGH TIME STATION — 1448 BASIN ST NW, Ephrata
GREEN THEORY — 10697 MAIN ST STE B, Bellevue
GREEN STAR CANNABIS — 1403 N DIVISION ST, Spokane
FREEDOM MARKET — 820A WESTSIDE HWY, Kelso
CREATIVE RETAIL MANAGEMENT — 7046 PACIFIC AVE,Tacoma
CASCADE KROPZ — 19129 SMOKEY POINT BLVD, Arlington
CANNABIS CITY — 2733 4TH AVE S, Seattle
BUD HUT — 1123 E STATE ROUTE 532, Camano Island
AUSTIN LOTT — 29 HORIZON FLATS RD, Winthrop
ALTITUDE – 260 MERLOT DR, Prosser
4US RETAIL — 23251 HWY 20, Okanogan
420 CARPENTER — 422 CARPENTER RD, Lacey
2020 SOLUTIONS – 2018 IRON ST, Bellingham]
Washingtonians will soon join residents of Colorado in the regulated cannabis market. The Washington State Liquor Control Board (WSLCB) suggests it will issu... From: Regulate Marijuana Views: 577 10 ratings Time: 01:49 More in Nonprofits & Activism